Sugi Predict

Sugi Predict / Compounds / SCHEMBL1892244

SCHEMBL1892244

SCHEMBL1892244

CC1(C)Cc2cccc(CO)c2O1

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.48
▸ ALDH1A1 P00352 2/20 0.44
▸ KDM4E B2RXH2 1/20 0.44
▸ PKM P14618 2/20 0.44
▸ NPSR1 Q6W5P4 1/20 0.44
▸ KMT2A Q03164 1/20 0.43
▸ KDM5A P29375 1/20 0.42
▸ KDM4C Q9H3R0 1/20 0.42
▸ POLB P06746 1/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ CCR8 P51685 1/20 0.42
▸ KCNH2 Q12809 1/20 0.42
▸ MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL321702 0.84 LMNA (0.49) LMNAALDH1A1KDM4EPKMNPSR1
SCHEMBL2432021 0.83 SSTR5 (0.44) LMNAKDM5AKDM4CCCR8KCNH2
SCHEMBL112586 0.83 LMNA (0.44) LMNAALDH1A1KDM4EPKMNPSR1
SCHEMBL8634114 0.83 LMNA (0.44) LMNAALDH1A1KDM4EPKMNPSR1
SCHEMBL10425052 0.83 LMNA (0.44) LMNAALDH1A1KDM4EPKMNPSR1
SCHEMBL6831429 0.81 LMNA (0.50) LMNAALDH1A1KDM4EPKMNPSR1
SCHEMBL4176360 0.81 LMNA (0.47) LMNAALDH1A1KDM4EPKMNPSR1
SCHEMBL14961223 0.80 NPC1 (0.49) LMNAALDH1A1KMT2AKDM5AKDM4C
SCHEMBL10425028 0.80 LMNA (0.43) LMNAALDH1A1KDM4EPKMNPSR1
SCHEMBL1252596 0.80 LMNA (0.49) LMNAALDH1A1KDM4EPKMNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113122062-A Quantum dot ink and preparation method of quantum dot film TCL集团股份有限公司 2021-07-16 — — CN claimed
CN-113122062-A Quantum dot ink and preparation method of quantum dot film TCL集团股份有限公司 2021-07-16 — — CN disclosed
EP-3763367-A1 PYRIDINE-PYRAZOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS Celgene Quanticel Research, Inc. (US) 2021-01-13 — — EP disclosed
EP-2928471-B1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2020-10-14 — — EP disclosed
US-10173996-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2019-01-08 — — US disclosed
US-9908865-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2018-03-06 — — US disclosed
US-20170275266-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2017-09-28 — — US disclosed
US-9714230-B2 Histone demethylase inhibitors Celgene Quantical Research, Inc. (US) 2017-07-25 — — US disclosed
US-20170158664-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2017-06-08 — — US disclosed
US-9604961-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2017-03-28 — — US disclosed
US-20090270359-A1 SUBSTITUTED PYRAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-10-29 — — US disclosed
US-20090176812-A1 HETEROMONOCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED 2009-07-09 — — US disclosed
EP-2074117-A2 HETEROMONOCYCLIC COMPOUND AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2009-07-01 — — EP disclosed
US-20080207654-A1 HETEROMONOCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED 2008-08-28 — — US disclosed
WO-2008062905-A2 HETEROMONOCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-05-29 — — WO disclosed
US-5712281-A Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines FMC CORPORATION (US) 1998-01-27 — — US disclosed
US-5536725-A Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines FMC CORPORATION (US) 1996-07-16 — — US disclosed
US-4748186-A NEMATOCIDES, ANTHELMINTICS FMC CORPORATION (US) 1988-05-31 — — US disclosed
WO-1988000183-A1 S-TRIFLUOROBUTENYL DERIVATIVES AND PESTICIDAL USES FMC CORPORATION (US) 1988-01-14 — — WO disclosed
CN-87104606-A S-trifluoro butenyl derivative and pesticidal use — 1988-01-13 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10173996-B2 Histone demethylase inhibitors KDM1B, KDM5A, KDM1A LMNA 3301/4885ALDH1A1 396/4885KDM4E 19/4885
US-20170275266-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM5A, KDM1A LMNA 3301/4885ALDH1A1 396/4885KDM4E 19/4885
US-20080207654-A1 HETEROMONOCYCLIC COMPOUND AND USE THEREOF C1R, C3AR1, C1S LMNA 2534/4885ALDH1A1 1982/4885KDM4E 4463/4885
US-20170158664-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM5A, KDM1A LMNA 3301/4885ALDH1A1 396/4885KDM4E 19/4885
US-20090176812-A1 HETEROMONOCYCLIC COMPOUND AND USE THEREOF C1R, C1S, C3AR1 LMNA 2114/4885ALDH1A1 1979/4885KDM4E 4304/4885
US-20090270359-A1 SUBSTITUTED PYRAZOLE DERIVATIVES AR, NR5A1, NR3C2 LMNA 4607/4885ALDH1A1 816/4885KDM4E 1440/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.