Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023312 | 0.80 | GAA (0.53) | GBA1POLBNPC1TDP1HPGD | |
| SCHEMBL15595060 | 0.79 | C3AR1 (0.45) | GBA1GRIN2B | |
| SCHEMBL15185034 | 0.78 | SMN1; SMN2 (0.53) | GBA1NPC1SMN1; SMN2MEN1RAB9A | |
| SCHEMBL9545617 | 0.78 | SMN1; SMN2 (0.53) | GBA1NPC1SMN1; SMN2MEN1RAB9A | |
| SCHEMBL27838457 | 0.78 | SMN1; SMN2 (0.53) | GBA1NPC1SMN1; SMN2MEN1RAB9A | |
| SCHEMBL10509156 | 0.76 | NPC1 (0.61) | POLBNPC1TDP1HPGDSMN1; SMN2 | |
| SCHEMBL10509164 | 0.76 | NPC1 (0.61) | POLBNPC1TDP1HPGDSMN1; SMN2 | |
| SCHEMBL2135825 | 0.75 | POLB (0.55) | POLBNPC1TDP1TSHRHPGD | |
| SCHEMBL15372290 | 0.74 | GBA1 (0.44) | GBA1GAACHRNB2CHRNA3CHRNA4 | |
| SCHEMBL18922681 | 0.74 | GBA1 (0.44) | GBA1GAACHRNB2CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670195-B2 | Glycosidase inhibitors and uses thereof | ALECTOS THERAPEUTICS INC. (CA) | 2017-06-06 | — | — | US | disclosed |