Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19656389 | 0.87 | ALDH1A1 (0.50) | PTPN1HPGDLMNARAB9ASMN1; SMN2 | |
| SCHEMBL9517500 | 0.86 | ALDH1A1 (0.68) | HPGDRAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21765873 | 0.86 | PTPN1 (0.88) | PTPN1HPGDLMNARAB9ASMN1; SMN2 | |
| SCHEMBL10201375 | 0.83 | SMN1; SMN2 (0.72) | PTPN1HPGDLMNARAB9ASMN1; SMN2 | |
| SCHEMBL25444035 | 0.81 | THRA (0.52) | HPGDRAB9AALDH1A1L3MBTL1GAA | |
| SCHEMBL836377 | 0.81 | PTPN1 (0.69) | PTPN1HPGDLMNARAB9ASMN1; SMN2 | |
| SCHEMBL3973349 | 0.81 | PTPN1 (0.69) | PTPN1HPGDLMNARAB9ASMN1; SMN2 | |
| SCHEMBL27922550 | 0.80 | KMT2A (0.72) | PTPN1HPGDLMNARAB9ASMN1; SMN2 | |
| SCHEMBL24438113 | 0.80 | PTPN1 (0.67) | PTPN1HPGDLMNARAB9ASMN1; SMN2 | |
| SCHEMBL10780544 | 0.79 | ALDH1A1 (0.56) | HPGDRAB9ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022232195-A2 | COVALENT APTAMERS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-11-03 | — | — | WO | disclosed |
| US-9669102-B2 | Cytotoxic benzodiazepine derivatives | IMMUNOGEN, INC. (US) | 2017-06-06 | — | — | US | disclosed |