Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18924456 | 0.87 | FASN (0.49) | POLBHPGDMAPK14NPC1RAB9A | |
| SCHEMBL18924451 | 0.84 | MAPK14 (0.48) | POLBHPGDMAPK14NPC1RAB9A | |
| SCHEMBL18924557 | 0.82 | FGFR1 (0.49) | POLBHPGDMAPK14NPC1RAB9A | |
| SCHEMBL16324462 | 0.81 | FASN (0.63) | FASN | |
| SCHEMBL18924523 | 0.75 | RXRB (0.50) | POLBHPGDMAPK14NPC1RAB9A | |
| SCHEMBL18924388 | 0.74 | POLB (0.50) | POLBHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL18924429 | 0.72 | MAPK14 (0.53) | POLBHPGDMAPK14NPC1RAB9A | |
| SCHEMBL18924337 | 0.72 | MAPK14 (0.55) | POLBHPGDMAPK14NPC1RAB9A | |
| SCHEMBL18924542 | 0.72 | MAPK14 (0.46) | POLBHPGDMAPK14NPC1RAB9A | |
| SCHEMBL16324460 | 0.72 | MAPK14 (0.35) | MAPK14TRPA1RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670142-B2 | 1,3-diaminocyclopentane carboxamide derivatives | MERCK PATENT GMBH (DE) | 2017-06-06 | — | — | US | disclosed |