Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK3 | P49761 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18924557 | 0.91 | FGFR1 (0.49) | MAPK14POLBCLK2CDK5CLK4 | |
| SCHEMBL18924391 | 0.84 | POLB (0.45) | MAPK14POLBS1PR1NPC1RAB9A | |
| SCHEMBL22259503 | 0.82 | GSK3B (0.56) | MAPK14CLK1DYRK3CLK2CLK3 | |
| SCHEMBL5410237 | 0.81 | AKT1 (0.48) | MAPK14POLBROCK2ROCK1CTNNB1 | |
| SCHEMBL16365082 | 0.80 | FASN (0.68) | MAPK14FASN | |
| SCHEMBL16324232 | 0.80 | FASN (0.68) | MAPK14FASN | |
| SCHEMBL18924533 | 0.79 | POLB (0.49) | MAPK14POLBS1PR1NPC1RAB9A | |
| SCHEMBL18924542 | 0.79 | MAPK14 (0.46) | MAPK14POLBDYRK1AS1PR1NPC1 | |
| SCHEMBL18924454 | 0.78 | DYRK1A (0.49) | MAPK14POLBDYRK1AS1PR1NPC1 | |
| SCHEMBL18924529 | 0.77 | POLB (0.46) | MAPK14POLBS1PR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670142-B2 | 1,3-diaminocyclopentane carboxamide derivatives | MERCK PATENT GMBH (DE) | 2017-06-06 | — | — | US | disclosed |