Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18924458 | 0.86 | DYRK1A (0.52) | DYRK1ANPC1RAB9AS1PR1MAPK1 | |
| SCHEMBL16323067 | 0.81 | FASN (0.62) | — | |
| SCHEMBL18924392 | 0.81 | MAPK14 (0.44) | POLBMAPK14NPC1RAB9AS1PR1 | |
| SCHEMBL18924451 | 0.78 | MAPK14 (0.48) | DYRK1APOLBMAPK14NPC1RAB9A | |
| SCHEMBL18924533 | 0.78 | POLB (0.49) | POLBMAPK14NPC1RAB9AS1PR1 | |
| SCHEMBL18924557 | 0.76 | FGFR1 (0.49) | POLBMAPK14NPC1RAB9AS1PR1 | |
| SCHEMBL16365762 | 0.76 | POLB (0.52) | POLBMAPK14NPC1RAB9AS1PR1 | |
| SCHEMBL18924542 | 0.76 | MAPK14 (0.46) | DYRK1APOLBMAPK14NPC1RAB9A | |
| SCHEMBL18924390 | 0.75 | SLC6A4 (0.47) | POLBMAPK14NPC1RAB9AALDH1A1 | |
| SCHEMBL18924529 | 0.74 | POLB (0.46) | POLBMAPK14NPC1RAB9AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670142-B2 | 1,3-diaminocyclopentane carboxamide derivatives | MERCK PATENT GMBH (DE) | 2017-06-06 | — | — | US | disclosed |