Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13662094 | 0.81 | HCAR3 (0.53) | CYP11B1CYP11B2HCAR3KDM4EALDH1A1 | |
| SCHEMBL19891749 | 0.79 | HCAR3 (0.50) | CYP11B1CYP11B2HCAR3KDM4EALDH1A1 | |
| SCHEMBL508376 | 0.78 | HCAR3 (0.53) | CYP11B1CYP11B2HCAR3KDM4EALDH1A1 | |
| SCHEMBL8104999 | 0.78 | HCAR3 (0.56) | CYP11B1CYP11B2HCAR3KDM4EALDH1A1 | |
| SCHEMBL24415724 | 0.76 | CYP11B1 (0.58) | CYP11B1CYP11B2HCAR3KDM4EL3MBTL1 | |
| SCHEMBL12867094 | 0.75 | HCAR3 (0.42) | CYP11B1CYP11B2HCAR3ALDH1A1NUDT1 | |
| SCHEMBL13657974 | 0.75 | HCAR3 (0.53) | HCAR3KDM4EALDH1A1L3MBTL1PDE10A | |
| SCHEMBL14217161 | 0.75 | HCAR3 (0.52) | CYP11B1CYP11B2HCAR3KDM4EALDH1A1 | |
| SCHEMBL22521538 | 0.74 | LMNA (0.42) | CYP11B1CYP11B2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL18924314 | 0.74 | HCAR3 (0.46) | CYP11B1CYP11B2HCAR3ALDH1A1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670172-B2 | Heterocyclic compounds and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2017-06-06 | — | — | US | disclosed |