Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17540833 | 0.83 | KDM4E (0.49) | KDM4ETARBP2RAB9ANPC1HRH3 | |
| SCHEMBL3886258 | 0.80 | KDM4E (0.50) | KDM4ETARBP2RAB9ANPC1HRH3 | |
| SCHEMBL7737637 | 0.80 | KDM4E (0.46) | KDM4ETARBP2RAB9ANPC1HRH3 | |
| SCHEMBL10480745 | 0.77 | SMN1; SMN2 (0.46) | KDM4ETARBP2RAB9ANPC1HRH3 | |
| SCHEMBL27597513 | 0.76 | HPGD (0.43) | KDM4ETARBP2RAB9ANPC1HRH3 | |
| SCHEMBL27536014 | 0.75 | KDM4E (0.49) | KDM4ETARBP2RAB9ANPC1HRH3 | |
| SCHEMBL4389204 | 0.75 | PPARG (0.47) | KDM4ETARBP2RAB9ANPC1HRH3 | |
| SCHEMBL27735469 | 0.75 | KDM4E (0.52) | KDM4ETARBP2HPGDPPARGPPARA | |
| SCHEMBL5215263 | 0.75 | RAB9A (0.43) | KDM4ETARBP2RAB9ANPC1HRH3 | |
| SCHEMBL4929594 | 0.73 | KDM4E (0.47) | KDM4ETARBP2RAB9ANPC1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670157-B2 | Benzylamine derivatives | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2017-06-06 | — | — | US | disclosed |