Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 8/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 3/20 | 0.30 |
| ▸ | CTSK | P43235 | 3/20 | 0.30 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.30 |
| ▸ | CTSS | P25774 | 2/20 | 0.30 |
| ▸ | CTSC | P53634 | 2/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18123328 | 1.00 | AKT1 (0.38) | AKT1EPHX2PDE10ASMOOPRM1 | |
| SCHEMBL21556664 | 1.00 | AKT1 (0.38) | AKT1EPHX2PDE10ASMOOPRM1 | |
| SCHEMBL21422792 | 0.89 | EPHX2 (0.42) | AKT1EPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL18123295 | 0.88 | CA12 (0.37) | AKT1SMOLTA4H | |
| SCHEMBL799022 | 0.78 | AKT1 (0.39) | AKT1EPHX2PDE10ASMOOPRM1 | |
| SCHEMBL799561 | 0.78 | AKT1 (0.39) | AKT1EPHX2PDE10ASMOOPRM1 | |
| SCHEMBL799377 | 0.78 | AKT1 (0.39) | AKT1EPHX2PDE10ASMOOPRM1 | |
| SCHEMBL16368600 | 0.77 | AKT1 (0.39) | AKT1EPHX2PDE10ASMOOPRM1 | |
| SCHEMBL16072923 | 0.77 | AKT1 (0.39) | AKT1EPHX2PDE10ASMOOPRM1 | |
| SCHEMBL13382854 | 0.76 | AKT1 (0.41) | AKT1EPHX2PDE10ASMOOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021214117-A1 | HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF | IOMX THERAPEUTICS AG (DE) | 2021-10-28 | — | — | WO | disclosed |
| US-10196402-B2 | CCR2 receptor antagonists and uses thereof | CENTREXION THERAPEUTICS CORPORATION (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170362249-A1 | NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | ANKURA TRUST COMPANY, LLC, AS ADMINISTRATIVE AND COLLATERAL AGENT | 2017-12-21 | — | — | US | disclosed |
| WO-2017186148-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE BCR-ABL INHIBITORS | ASTAR BIOTECH LLC (US) | 2017-11-02 | — | — | WO | disclosed |
| US-9670222-B2 | CCR2 receptor antagonists and uses thereof | CENTREXION THERAPEUTICS CORPORATION (US) | 2017-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196402-B2 | CCR2 receptor antagonists and uses thereof | CCR2, CCRL2, CCR1 | AKT1 3541/4885EPHX2 537/4885PDE10A 2854/4885 |
| US-20170362249-A1 | NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | CCR2, CCRL2, CCR1 | AKT1 3582/4885EPHX2 527/4885PDE10A 2639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.