Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | NOS2 | P35228 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13438556 | 1.00 | AR (0.40) | ARNOS2LMNATSHRMEN1 | |
| SCHEMBL5661864 | 1.00 | AR (0.40) | ARNOS2LMNATSHRMEN1 | |
| SCHEMBL8266212 | 1.00 | AR (0.40) | ARNOS2LMNATSHRMEN1 | |
| SCHEMBL7252266 | 0.96 | LMNA (0.41) | ARNOS2LMNATSHRMEN1 | |
| SCHEMBL18925342 | 0.89 | MEN1 (0.35) | ARNOS2MEN1KMT2AGAA | |
| SCHEMBL20750781 | 0.89 | MEN1 (0.35) | ARNOS2MEN1KMT2AGAA | |
| SCHEMBL27709542 | 0.83 | LMNA (0.39) | NOS2LMNATSHRMEN1KMT2A | |
| SCHEMBL30417082 | 0.82 | CHRNB4 (0.39) | LMNAMEN1KMT2AGAA | |
| SCHEMBL17075140 | 0.81 | PRCP (0.37) | NOS2LMNATSHRHTR2CPRCP | |
| SCHEMBL15187569 | 0.81 | PRCP (0.40) | NOS2LMNATSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671196-B2 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | WYETH LLC (US) | 2010-03-02 | — | — | US | disclosed |
| US-7671196-B2 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | WYETH LLC (US) | 2010-03-02 | — | — | US | disclosed |
| US-7671196-B2 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | WYETH LLC (US) | 2010-03-02 | — | — | US | disclosed |
| US-20100022519-A1 | HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. | 2010-01-28 | — | — | US | disclosed |
| EP-1907390-A2 | DIAZEPINOQUINOLINES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | Wyeth a Corporation of the State of Delaware (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007016029-A2 | DIAZEPINOQUINOLINES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007016029-A2 | DIAZEPINOQUINOLINES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027142-A1 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070027142-A1 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070027142-A1 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022519-A1 | HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF | TRPV1, P2RX4, TRPA1 | AR 2916/4885NOS2 483/4885LMNA 1965/4885 |
| US-20070027142-A1 | Diazepinoquinolines, synthesis thereof, and intermediates thereto | HTR2C, HTR3B, HTR2A | AR 1333/4885NOS2 414/4885LMNA 1554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.