Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.60 |
| ▸ | FER | P16591 | 6/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.47 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.47 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20750745 | 1.00 | SYK (0.60) | SYKFERKCNH2JAK2LCK | |
| SCHEMBL2713832 | 0.91 | SYK (0.72) | SYKFERKCNH2JAK2LCK | |
| SCHEMBL20750800 | 0.91 | SYK (0.57) | SYKFER | |
| SCHEMBL18925371 | 0.91 | SYK (0.63) | SYKFERKCNH2JAK2LCK | |
| SCHEMBL18925372 | 0.91 | SYK (0.63) | SYKFERKCNH2JAK2LCK | |
| SCHEMBL18925999 | 0.89 | SYK (0.60) | SYKFERKCNH2JAK2LCK | |
| SCHEMBL18925617 | 0.88 | SYK (0.62) | SYKFERKCNH2JAK2LCK | |
| SCHEMBL18925273 | 0.87 | SYK (0.63) | SYKFER | |
| SCHEMBL5027951 | 0.82 | SYK (0.74) | SYKFERKCNH2JAK2LCK | |
| SCHEMBL20750869 | 0.82 | FER (0.48) | SYKFERKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |
| US-20150272956-A1 | SUBSTITUTED XANTHINE DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150272956-A1 | SUBSTITUTED XANTHINE DERIVATIVES | XDH, HPRT1, CXCR3 | SYK 2450/4885FER 3205/4885KCNH2 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.