Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.44 |
| ▸ | CNR1 | P21554 | 8/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17465534 | 0.80 | CES2 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL826770 | 0.80 | CES2 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27995445 | 0.78 | CES2 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27995447 | 0.78 | CNR1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30053288 | 0.75 | MEN1 (0.52) | CNR1MEN1POLBKMT2A | |
| SCHEMBL10247809 | 0.74 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4064040 | 0.74 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17466750 | 0.73 | CNR1 (0.48) | CNR1CES2CES1 | |
| SCHEMBL121043 | 0.73 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18652267 | 0.73 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093992-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME LLC | 2018-04-05 | — | — | US | disclosed |
| US-20170158701-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME LLC | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093992-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | DPP4, PEPD, DPP9 | PSEN1 1506/4885PSEN2 1840/4885APH1B 830/4885 |
| US-20170158701-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | DPP4, PEPD, DPP9 | PSEN1 1464/4885PSEN2 1820/4885APH1B 798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.