Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28803843 | 0.82 | SERPINH1 (0.31) | SERPINH1 | |
| SCHEMBL17465534 | 0.78 | CES2 (0.45) | CNR1ATMTDP1SERPINH1CES2 | |
| SCHEMBL18925501 | 0.78 | PSEN1 (0.44) | CNR1ATMTDP1SERPINH1CES2 | |
| SCHEMBL826770 | 0.78 | CES2 (0.45) | CNR1ATMTDP1SERPINH1CES2 | |
| SCHEMBL2337689 | 0.76 | ATM (0.42) | CNR1ATMTDP1CES2CES1 | |
| SCHEMBL27995445 | 0.75 | CES2 (0.43) | CNR1ATMTDP1SERPINH1CES2 | |
| SCHEMBL28038735 | 0.70 | CES2 (0.35) | CES2CES1PSEN1PSEN2APH1B | |
| SCHEMBL28136400 | 0.68 | ATM (0.44) | CNR1ATMTDP1CES2CES1 | |
| SCHEMBL121043 | 0.68 | PSEN1 (0.40) | CNR1CES2CES1PSEN1PSEN2 | |
| SCHEMBL1444104 | 0.68 | PSEN1 (0.45) | CNR1ATMTDP1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106543189-A | A kind of dipeptidyl peptidase-iv inhibitor | 成都硕鼎科技有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-106543187-A | A kind of amino tetrahydro pyran derivative | 成都贝斯凯瑞生物科技有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-106543188-A | A kind of amino tetrahydro pyran derivant and its purposes in medicine | 成都融科博海科技有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-105622612-A | Aminotetrahydropyran derivative used as dipeptidyl peptidase-IV inhibitor | CHENGDU BESS CARREY BIOTECHNOLOGY CO LTD | 2016-06-01 | — | — | CN | disclosed |
| CN-105085528-A | Aminotetrahydropyran derivative as dipeptidyl peptidase-IV inhibitor | CHENGDU BEISIKAIRUI BIOTECHNOLOGY CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-102272136-B | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME | 2015-01-14 | — | — | CN | disclosed |