Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.45 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPY1R | P25929 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21504170 | 1.00 | GAA (0.66) | GAAL3MBTL1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL20750746 | 1.00 | GAA (0.66) | GAAL3MBTL1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL30872892 | 1.00 | GAA (0.66) | GAAL3MBTL1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3668041 | 0.80 | GAA (1.00) | GAAL3MBTL1KCNQ3KCNQ2EPHX1 | |
| SCHEMBL3671016 | 0.79 | GAA (0.96) | GAAL3MBTL1KCNQ3KCNQ2EPHX1 | |
| SCHEMBL21104687 | 0.79 | GAA (0.96) | GAAL3MBTL1KCNQ3KCNQ2EPHX1 | |
| SCHEMBL28091017 | 0.79 | GAA (0.96) | GAAL3MBTL1KCNQ3KCNQ2EPHX1 | |
| SCHEMBL3665297 | 0.79 | GAA (0.96) | GAAL3MBTL1KCNQ3KCNQ2EPHX1 | |
| Hydrochloric Acid SCHEMBL28720089 | 0.77 | GAA (0.93) | GAAL3MBTL1EPHX1LMNAHPGD | |
| SCHEMBL21997439 | 0.77 | GAA (0.58) | GAAL3MBTL1KCNQ3KCNQ2KCNQ4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-B1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARM INC (US) | 2019-02-20 | — | — | EP | disclosed |
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |