Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18925836 | 0.89 | CCNC (0.45) | ALDH1A1LMNANTRK1MAPK13MAPK14 | |
| SCHEMBL17130158 | 0.89 | ALDH1A1 (0.52) | ALDH1A1LMNAJAK2NTRK1MAPK13 | |
| SCHEMBL17130156 | 0.87 | ALDH1A1 (0.50) | ALDH1A1LMNAJAK2NTRK1MAPK13 | |
| SCHEMBL18694530 | 0.86 | ALDH1A1 (0.48) | ALDH1A1LMNAJAK2NTRK1MAPK13 | |
| SCHEMBL17130159 | 0.86 | ALDH1A1 (0.47) | ALDH1A1LMNAJAK2NTRK1MAPK13 | |
| SCHEMBL18693864 | 0.81 | ALDH1A1 (0.56) | ALDH1A1LMNAJAK2NTRK1MAPK13 | |
| SCHEMBL18694207 | 0.80 | MAPK13 (0.56) | JAK2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL18694618 | 0.79 | NTRK1 (0.47) | ALDH1A1LMNAJAK2NTRK1MAPK13 | |
| SCHEMBL18694788 | 0.79 | NTRK1 (0.48) | JAK2NTRK1MAPK13MAPK12MAPK11 | |
| SCHEMBL17130176 | 0.78 | NTRK1 (0.46) | ALDH1A1LMNANTRK1MAPK14CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914736-B2 | TrKA kinase inhibitors, compositions and methods thereof | MERCK SHARP & DOHME CORP. (US) | 2018-03-13 | — | — | US | disclosed |
| US-20170158698-A1 | TrKA Kinase Inhibitors, Compositions and Methods Thereof | MERCK SHARP & DOHME CORP. (US) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158698-A1 | TrKA Kinase Inhibitors, Compositions and Methods Thereof | NGFR, NGF, NTRK2 | ALDH1A1 3941/4885LMNA 1452/4885JAK2 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.