SCHEMBL1892590

SCHEMBL1892590

CC1(F)C=CC(C(=O)O)C=C1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.32
CTDSP1 Q9GZU7 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
APLNR P35414 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11543961 0.76 POLB (0.32) POLBCTDSP1TDP1APLNR
SCHEMBL7707621 0.76 POLB (0.32) POLBCTDSP1TDP1APLNR
SCHEMBL23270880 0.73
SCHEMBL8381187 0.70 ALDH1A1 (0.30) TDP1
SCHEMBL3692353 0.70
SCHEMBL3100507 0.70
SCHEMBL4104220 0.69
SCHEMBL1226420 0.69 POLB (0.47) POLBCTDSP1TDP1
SCHEMBL21812046 0.68 GRM4 (0.30) TDP1
SCHEMBL2999674 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1797186-B1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NAT RES COUNCIL CANADA (CA) 2016-05-25 EP claimed
US-8728759-B2 Reverse cumate repressor mutant NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2014-05-20 US claimed
US-8252556-B2 Reverse cumate repressor mutant NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2012-08-28 US claimed
US-20110171686-A1 REVERSE CUMATE REPRESSOR MUTANT NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2011-07-14 US claimed
US-20090176275-A1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2009-07-09 US claimed
US-20080311618-A1 Expression System, Components Thereof and Methods of Use NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2008-12-18 US claimed
EP-1797186-A4 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE CA NAT RESEARCH COUNCIL (CA) 2008-11-12 EP claimed
EP-1797186-A1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2007-06-20 EP claimed
WO-2006037215-A1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2006-04-13 WO claimed
US-20040205834-A1 System for inducible expression in eukaryotic cells NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2004-10-14 US claimed
US-12351813-B2 Tetracycline-inducible expression system DNA TWOPOINTO INC. (US) 2025-07-08 US disclosed
US-20240425875-A1 EXPRESSION SYSTEM FOR CONSTITUTIVE OR CUMATE-INDUCIBLE EXPRESSION IN CHO CELLS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2024-12-26 US disclosed
EP-4402273-A1 EXPRESSION SYSTEM FOR CONSTITUTIVE OR CUMATE-INDUCIBLE EXPRESSION IN CHO CELLS National Research Council of Canada (CA) 2024-07-24 EP disclosed
US-20230323396-A1 TETRACYCLINE-INDUCIBLE EXPRESSION SYSTEM DNA TWOPOINTO INC. (US) 2023-10-12 US disclosed
WO-2023037338-A1 EXPRESSION SYSTEM FOR CONSTITUTIVE OR CUMATE-INDUCIBLE EXPRESSION IN CHO CELLS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2023-03-16 WO disclosed
US-20080311618-A1 Expression System, Components Thereof and Methods of Use NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2008-12-18 US disclosed
EP-1797186-A4 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE CA NAT RESEARCH COUNCIL (CA) 2008-11-12 EP disclosed
EP-1797186-A1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2007-06-20 EP disclosed
WO-2006037215-A1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2006-04-13 WO disclosed
US-20040205834-A1 System for inducible expression in eukaryotic cells NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2004-10-14 US disclosed