Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7626818 | 0.88 | CYP3A4 (0.46) | APAF1CASP6KDM4EALDH1A1HPGD | |
| SCHEMBL10947288 | 0.86 | CYP3A4 (0.38) | APAF1CASP6KDM4EALDH1A1HPGD | |
| SCHEMBL4322373 | 0.75 | CYP3A4 (0.54) | APAF1CASP6KDM4EALDH1A1CYP3A4 | |
| SCHEMBL515776 | 0.75 | ALDH1A1 (0.54) | APAF1CASP6KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL27932628 | 0.73 | CYP3A4 (0.53) | APAF1CASP6KDM4EALDH1A1HPGD | |
| SCHEMBL27932684 | 0.72 | CYP3A4 (0.44) | APAF1CASP6KDM4EALDH1A1HPGD | |
| SCHEMBL14879818 | 0.70 | PMP22 (0.53) | ALDH1A1GLACYP3A4PMP22MAPT | |
| SCHEMBL17682322 | 0.69 | CYP3A4 (0.41) | APAF1CASP6KDM4EALDH1A1GAA | |
| SCHEMBL28324506 | 0.69 | LMNA (0.41) | KDM4EALDH1A1CYP3A4PMP22LMNA | |
| SCHEMBL7605281 | 0.69 | CYP3A4 (0.41) | APAF1CASP6KDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180251854-A1 | Method For Predicting Therapy Responsiveness In Basal Like Tumors | WIRTZ RALPH MARKUS (DE) | 2018-09-06 | — | — | US | disclosed |
| US-9932639-B2 | Method for predicting therapy responsiveness in basal like tumors | WIRTZ RALPH MARKUS (DE) | 2018-04-03 | — | — | US | disclosed |
| CN-102264235-A | Food product fortified with methylxanthines | — | 2011-11-30 | — | — | CN | disclosed |
| EP-2369939-A2 | FOOD PRODUCTS ENRICHED WITH METHYLXANTHINES | Unilever PLC (GB) | 2011-10-05 | — | — | EP | disclosed |
| US-20110118129-A1 | METHOD FOR PREDICTING THERAPY RESPONSIVENESS IN BASAL LIKE TUMORS | Wirtz, Ralph Markus (DE) | 2011-05-19 | — | — | US | disclosed |
| EP-2215251-A2 | METHOD FOR PREDICTING THERAPY RESPONSIVENESS IN BASAL LIKE TUMORS | Siemens Healthcare Diagnostics GmbH (DE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2010076112-A2 | FOOD PRODUCTS ENRICHED WITH METHYLXANTHINES | UNILEVER PLC (GB) | 2010-07-08 | — | — | WO | disclosed |
| WO-2009068423-A2 | METHOD FOR PREDICTING THERAPY RESPONSIVENESS IN BASAL LIKE TUMORS | SIEMENS HEALTHCARE DIAGNOSTICS GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |