Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19382047 | 0.80 | HDAC8 (0.41) | SMN1; SMN2HTTHPGDHSD17B10KDM4E | |
| SCHEMBL18930965 | 0.80 | HSD17B10 (0.53) | HTTHPGDHSD17B10KDM4ETSHR | |
| SCHEMBL18930822 | 0.79 | HSD17B10 (0.40) | LMNAHTTHPGDHSD17B10KDM4E | |
| SCHEMBL13362102 | 0.78 | HTT (0.57) | SMN1; SMN2LMNAHTTHPGDHSD17B10 | |
| SCHEMBL27408729 | 0.78 | TDP1 (0.42) | HPGDHSD17B10KDM4ETSHRKMT2A | |
| SCHEMBL23505931 | 0.77 | HPGD (0.39) | SMN1; SMN2LMNAHTTHPGDKDM4E | |
| SCHEMBL12684764 | 0.76 | HDAC1 (0.60) | SMN1; SMN2LMNAHTTHPGDHSD17B10 | |
| SCHEMBL10873524 | 0.76 | IDO1 (0.56) | SMN1; SMN2LMNAHTTHPGDHSD17B10 | |
| SCHEMBL15854548 | 0.76 | HDAC8 (0.60) | SMN1; SMN2LMNAHTTHPGDHSD17B10 | |
| SCHEMBL1519151 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHTTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024076891-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| EP-2556070-B1 | SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES | UNIV HEALTH NETWORK (CA) | 2017-06-07 | — | — | EP | disclosed |