Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19382047 | 0.82 | HDAC8 (0.41) | KDM4EHSD17B10HPGDTSHRPTPN1 | |
| SCHEMBL18930487 | 0.78 | SMN1; SMN2 (0.50) | KDM4EHSD17B10HPGDTSHRPTPN1 | |
| SCHEMBL20801152 | 0.77 | HSD17B10 (0.42) | TDP1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL18930965 | 0.76 | HSD17B10 (0.53) | TDP1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL18930822 | 0.75 | HSD17B10 (0.40) | KDM4EHSD17B10HPGDTSHRPTPN1 | |
| SCHEMBL14392043 | 0.75 | HSD17B10 (0.45) | KDM4EHSD17B10HPGDTSHRPTPN1 | |
| SCHEMBL19382082 | 0.72 | IDO1 (0.47) | KDM4EHSD17B10HPGDTSHRIDO1 | |
| SCHEMBL14000510 | 0.70 | ALDH1A1 (0.64) | HSD17B10HPGDALDH1A1KMT2APOLB | |
| SCHEMBL14684575 | 0.70 | KDM4E (0.49) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL3159306 | 0.68 | HSD17B10 (0.52) | TDP1KDM4EHSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024076891-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |