Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CCNC | P24863 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18930487 | 0.78 | SMN1; SMN2 (0.50) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL6857685 | 0.74 | HTT (0.56) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL17845927 | 0.73 | LMNA (1.00) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL13917362 | 0.70 | HTT (0.45) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL18171881 | 0.69 | PDGFRB (0.61) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL22084443 | 0.69 | BACE1 (0.40) | HTTLMNASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL14684575 | 0.68 | KDM4E (0.49) | SMN1; SMN2KDM4EASPHRIOX2KDM8 | |
| SCHEMBL7349396 | 0.67 | KMT2A (0.51) | HTTLMNASMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL21055794 | 0.67 | PDE5A (0.71) | HTTLMNASMN1; SMN2RXFP1PDE5A | |
| SCHEMBL21055798 | 0.66 | LMNA (0.59) | HTTLMNASMN1; SMN2PDE5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155527-A9 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2009155527-A2 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |