Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 5/20 | 0.55 |
| ▸ | DAGLA | Q9Y4D2 | 5/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 3/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20576126 | 0.86 | ABHD6 (0.58) | ABHD6DAGLAABCB1 | |
| SCHEMBL18935778 | 0.85 | ABHD6 (0.54) | ABHD6DAGLANR1H2NR1H3DPP4 | |
| SCHEMBL273407 | 0.80 | NR1H2 (0.59) | ABHD6DAGLANR1H2NR1H3DPP4 | |
| SCHEMBL271604 | 0.80 | NR1H2 (0.59) | ABHD6DAGLANR1H2NR1H3DPP4 | |
| SCHEMBL5637318 | 0.80 | NR1H2 (0.59) | ABHD6DAGLANR1H2NR1H3DPP4 | |
| SCHEMBL18936258 | 0.80 | NR1H2 (0.50) | ABHD6DAGLANR1H2NR1H3DPP4 | |
| SCHEMBL18935776 | 0.80 | NR1H2 (0.50) | ABHD6DAGLANR1H2NR1H3DPP4 | |
| SCHEMBL23632150 | 0.78 | ABCB1 (0.51) | NR1H2NR1H3ABCB1JAK2JAK1 | |
| SCHEMBL14457250 | 0.77 | ABCB1 (0.58) | ABHD6DAGLANR1H2NR1H3DPP4 | |
| SCHEMBL28334140 | 0.77 | NR1H2 (0.56) | DAGLANR1H2NR1H3DPP4ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017096315-A1 | TRIAZOLE DAGL(α) INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-06-08 | — | — | WO | disclosed |