SCHEMBL18936367

SCHEMBL18936367

CCCCOCCCC(=O)c1ccccc1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 2/20 0.49
WNT3A P56704 2/20 0.49
TSHR P16473 5/20 0.49
L3MBTL1 Q9Y468 3/20 0.49
TDP1 Q9NUW8 2/20 0.49
HDAC3 O15379 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC2 Q92769 1/20 0.48
RARA P10276 1/20 0.44
RARB P10826 1/20 0.44
CYP3A4 P08684 2/20 0.44
MAPK1 P28482 2/20 0.44
PTPN1 P18031 1/20 0.44
ERCC5 P28715 1/20 0.44
FEN1 P39748 1/20 0.44
TP53 P04637 1/20 0.44
CCNB2 O95067 1/20 0.44
CCNE2 O96020 1/20 0.44
CDK1 P06493 1/20 0.44
CDK4 P11802 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18936230 0.94 CTNNB1 (0.49) CTNNB1WNT3ATSHRL3MBTL1TDP1
SCHEMBL6757360 0.87 HDAC3 (0.55) CTNNB1WNT3AHDAC3HDAC1HDAC2
SCHEMBL13193216 0.86 TSHR (0.50) CTNNB1WNT3ATSHRL3MBTL1TDP1
SCHEMBL11765622 0.85 HDAC3 (0.54) CTNNB1WNT3AHDAC3HDAC1HDAC2
SCHEMBL28223126 0.84 HDAC3 (0.53) CTNNB1WNT3ATSHRHDAC3HDAC1
SCHEMBL10594894 0.84 HDAC3 (0.53) CTNNB1WNT3ATSHRHDAC3HDAC1
SCHEMBL14732971 0.82 CTNNB1 (0.61) CTNNB1WNT3ATDP1PTPN1ERCC5
SCHEMBL18936355 0.81 NPC1 (0.48) CTNNB1WNT3ATSHRL3MBTL1TDP1
SCHEMBL3121320 0.80 ALDH1A1 (0.57) CTNNB1WNT3ATSHRL3MBTL1TDP1
SCHEMBL15061010 0.80 FFAR1 (0.51) L3MBTL1CYP3A4MAPK1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017095759-A1 C5-C6-CARBOCYCLIC FUSED IMINOTHIADIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE MERCK SHARP & DOHME CORP. (US) 2017-06-08 WO disclosed