Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl 3-Phenylpropanoate SCHEMBL168711 | 0.98 | TDP1 (0.68) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL27447160 | 0.96 | TDP1 (0.66) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL27315471 | 0.96 | TDP1 (0.66) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL17748824 | 0.94 | TDP1 (0.63) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL27364391 | 0.94 | TDP1 (0.63) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL213543 | 0.92 | KEAP1 (0.70) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL9424369 | 0.92 | TDP1 (0.61) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL27822992 | 0.91 | TDP1 (0.59) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL28004669 | 0.91 | TDP1 (0.59) | TDP1CA12CA7CA9CA14 | |
| Methyl 3-Phenylpropanoate SCHEMBL27506579 | 0.91 | KEAP1 (0.68) | TDP1CA12CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10111846-B2 | S isomers of alpha-methyl-hydrocinnamic acid for the treatment of blood disorders | PERRINE SUSAN PARK (US) | 2018-10-30 | — | — | US | disclosed |
| US-20170312235-A1 | S ISOMERS OF ALPHA-METHYL-HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS | PERRINE SUSAN PARK (US) | 2017-11-02 | — | — | US | disclosed |
| US-9603818-B2 | S isomers of alpha-methyl-hydrocinnamic acid for the treatment of blood disorders | PERRINE SUSAN PARK (US) | 2017-03-28 | — | — | US | disclosed |
| US-20160151315-A1 | S ISOMERS OF ALPHA-METHYL-HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS | PERRINE SUSAN PARK (US) | 2016-06-02 | — | — | US | disclosed |
| US-9173860-B2 | S isomers of α-methyl hydrocinnamic acid for the treatment of blood disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-03 | — | — | US | disclosed |
| US-20120283329-A1 | S ISOMERS OF ALPHA-METHYL HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-11-08 | — | — | US | disclosed |
| WO-2011056978-A2 | S ISOMERS OF ALPHA-METHYL HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10111846-B2 | S isomers of alpha-methyl-hydrocinnamic acid for the treatment of blood disorders | HPGDS, HBG1, HCLS1 | TDP1 2350/4885CA12 2787/4885CA7 160/4885 |
| US-20160151315-A1 | S ISOMERS OF ALPHA-METHYL-HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS | HPGDS, HBG1, HCLS1 | TDP1 2350/4885CA12 2787/4885CA7 160/4885 |
| US-20120283329-A1 | S ISOMERS OF ALPHA-METHYL HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS | HBG1, HPGDS, HCLS1 | TDP1 2367/4885CA12 2249/4885CA7 128/4885 |
| US-20170312235-A1 | S ISOMERS OF ALPHA-METHYL-HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS | HPGDS, HBG1, HCLS1 | TDP1 2350/4885CA12 2787/4885CA7 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.