Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21555502 | 0.98 | HTT (0.49) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25007284 | 0.97 | HTT (0.50) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19295481 | 0.97 | HTT (0.50) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20366360 | 0.94 | HTT (0.48) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24858435 | 0.94 | SMN1; SMN2 (0.46) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18610658 | 0.91 | HTT (0.48) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18409015 | 0.90 | SMN1; SMN2 (0.46) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21713229 | 0.85 | PKM (0.49) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18411010 | 0.83 | SMN1; SMN2 (0.49) | PKMHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24176500 | 0.83 | L3MBTL1 (0.49) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957268-B2 | 1H-pyrrolo[2,3,c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins | INCYTE CORPORATION (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170158689-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | INCYTE CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158689-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | BRD3, BRD1, BRD2 | PKM 3325/4885HTT 1512/4885MEN1 2471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.