SCHEMBL18939015

SCHEMBL18939015

N=C(N)c1cc(F)c(Cn2ccc3ncccc32)c(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PLAU P00749 4/20 0.41
SLC22A12 Q96S37 1/20 0.41
MET P08581 2/20 0.37
RPS6KA5 O75582 2/20 0.37
PLG P00747 2/20 0.36
RORC P51449 6/20 0.36
GRIN2B Q13224 2/20 0.35
NR3C1 P04150 1/20 0.34
PGR P06401 1/20 0.34
NR3C2 P08235 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL18939169 0.88 SLC22A12 (0.45) SLC22A12METRPS6KA5RORCGRIN2B
SCHEMBL18960813 0.85 SLC22A12 (0.38) SLC22A12METRPS6KA5RORCGRIN2B
Hydrochloric Acid SCHEMBL18938985 0.84 SLC22A12 (0.37) SLC22A12METRPS6KA5RORCGRIN2B
SCHEMBL18967497 0.83 SLC22A12 (0.36) SLC22A12METRPS6KA5RORCGRIN2B
SCHEMBL18977649 0.81 PLAU (0.46) PLAUMETPLGGRIN2B
SCHEMBL18977913 0.81 GRIN2B (0.43) SLC22A12METRPS6KA5GRIN2BNR3C1
SCHEMBL18939270 0.79 PLAU (0.46) PLAUSLC22A12PLGRORC
SCHEMBL18960814 0.79 SLC22A12 (0.37) SLC22A12METRORCGRIN2BNR3C1
SCHEMBL18939019 0.78 PLAU (0.48) PLAUSLC22A12PLG
SCHEMBL18939091 0.78 RPS6KA5 (0.41) SLC22A12METRPS6KA5GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108463461-B Cephem compounds, their preparation and use 奈加-RGM制药有限公司 2021-11-19 CN disclosed
US-RE48097-E1 Cephem compounds, their production and use NAEJA-RGM PHARMACEUTICALS ULC (CA) 2020-07-14 US disclosed
US-RE48097-E1 Cephem compounds, their production and use NAEJA-RGM PHARMACEUTICALS ULC (CA) 2020-07-14 US disclosed
US-9751894-B2 Cephem compounds, their production and use NAEJA-RGM PHARMACEUTICALS INC. (CA) 2017-09-05 US disclosed
US-9751894-B2 Cephem compounds, their production and use NAEJA-RGM PHARMACEUTICALS INC. (CA) 2017-09-05 US disclosed
US-9751894-B2 Cephem compounds, their production and use NAEJA-RGM PHARMACEUTICALS INC. (CA) 2017-09-05 US disclosed
WO-2017096472-A1 CEPHEM COMPOUNDS, THEIR PRODUCTION AND USE NAEJA-RGM PHARMACEUTICALS INC. (CA) 2017-06-15 WO disclosed
US-20170166587-A1 CEPHEM COMPOUNDS, THEIR PRODUCTION AND USE NAEJA-RGM PHARMACEUTICALS ULC (CA) 2017-06-15 US disclosed
US-20170166587-A1 CEPHEM COMPOUNDS, THEIR PRODUCTION AND USE NAEJA-RGM PHARMACEUTICALS ULC (CA) 2017-06-15 US disclosed
US-20170166587-A1 CEPHEM COMPOUNDS, THEIR PRODUCTION AND USE NAEJA-RGM PHARMACEUTICALS ULC (CA) 2017-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170166587-A1 CEPHEM COMPOUNDS, THEIR PRODUCTION AND USE CEP170, AADAC, NAA50 PLAU 4395/4885SLC22A12 2800/4885MET 1902/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.