Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 6/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.44 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891048 | 0.90 | FEN1 (0.49) | FEN1ALOX5APMPLMAPK1MAP2K4 | |
| SCHEMBL1885446 | 0.86 | MEN1 (0.47) | FEN1ALOX5APMPLADORA2AMEN1 | |
| SCHEMBL1888242 | 0.82 | FEN1 (0.49) | FEN1ALOX5APMPLMAPK1MAP2K4 | |
| SCHEMBL1891742 | 0.80 | MAP2K4 (0.48) | FEN1ALOX5APMPLMAP2K4ADORA2A | |
| SCHEMBL1891905 | 0.80 | HSD11B1 (0.50) | FEN1ALOX5APMPLADORA2AADORA1 | |
| SCHEMBL1894636 | 0.79 | CTSA (0.45) | FEN1ALOX5APMPLADORA2AADORA1 | |
| SCHEMBL1655716 | 0.77 | ADORA2A (0.48) | FEN1ALOX5APMPLMAPK1ADORA2A | |
| SCHEMBL2386527 | 0.76 | ADORA2A (0.43) | FEN1ALOX5APMPLADORA2AKMT2A | |
| SCHEMBL1893696 | 0.76 | FEN1 (0.47) | FEN1ALOX5APMPLMAPK1MAP2K4 | |
| SCHEMBL2386650 | 0.74 | MPL (0.41) | FEN1ALOX5APMPLADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105543-A1 | NOVEL TRIARYL DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2011-05-05 | — | — | US | claimed |
| CN-101970406-A | Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors | NEUROSEARCH AS | 2011-02-09 | — | — | CN | claimed |
| US-20110105543-A1 | NOVEL TRIARYL DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2011-05-05 | — | — | US | disclosed |
| CN-101970406-A | Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors | NEUROSEARCH AS | 2011-02-09 | — | — | CN | disclosed |
| EP-2262767-A1 | NOVEL TRIARYL DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NeuroSearch A/S (DK) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009112461-A1 | NOVEL TRIARYL DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105543-A1 | NOVEL TRIARYL DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA5, CHRNA3, CHRM3 | FEN1 4851/4885ALOX5AP 2582/4885MPL 4052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.