Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21689072 | 0.86 | HPGDS (0.59) | EGFRHPGDSHTTKDM4EALDH1A1 | |
| SCHEMBL3879836 | 0.79 | HPGDS (0.47) | HPGDSHTTKDM4EALDH1A1CDC7 | |
| SCHEMBL12850560 | 0.79 | HPGDS (0.47) | HPGDSHTTKDM4EALDH1A1CDC7 | |
| SCHEMBL4949489 | 0.79 | HPGDS (0.47) | HPGDSHTTALDH1A1CDC7MAP4K4 | |
| SCHEMBL15125079 | 0.79 | HPGDS (0.51) | HPGDSKDM4EALDH1A1TSHRGAA | |
| SCHEMBL12850742 | 0.79 | HPGDS (0.47) | HPGDSHTTALDH1A1CDC7MAP4K4 | |
| SCHEMBL11162210 | 0.78 | EGFR (0.61) | EGFRHTTKDM4EALDH1A1TP53 | |
| SCHEMBL30503636 | 0.78 | EGFR (0.61) | EGFRHTTKDM4EALDH1A1TP53 | |
| Aniline SCHEMBL28107592 | 0.78 | ALDH1A1 (0.49) | HPGDSHTTKDM4EALDH1A1CDC7 | |
| SCHEMBL63442 | 0.76 | ALDH1A1 (0.57) | EGFRHPGDSKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983064-B1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES INC (US) | 2024-03-06 | — | — | EP | disclosed |
| CN-112679473-B | Lenatinib intermediate crystal, preparation method and application thereof | 四川科伦药物研究院有限公司 | 2024-03-05 | — | — | CN | disclosed |
| CN-109422755-B | Nitrogen-containing heterocyclic compound, preparation method, intermediate, composition and application | 上海医药集团股份有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-112679473-A | Lenalitinib intermediate crystal, preparation method and application thereof | 四川科伦药物研究院有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-108026067-B | 6-amino-quinoline-3-carbonitriles as COT modulators | 吉利德科学公司 | 2021-01-12 | — | — | CN | disclosed |
| CN-108026067-B | 6-amino-quinoline-3-carbonitriles as COT modulators | 吉利德科学公司 | 2021-01-12 | — | — | CN | disclosed |
| CN-108026067-A | 6- amino-quinolin -3- nitriles as COT conditioning agents | 吉利德科学公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-108026067-A | 6- amino-quinolin -3- nitriles as COT conditioning agents | 吉利德科学公司 | 2018-05-11 | — | — | CN | disclosed |
| EP-2896612-A1 | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors | Wyeth Holdings LLC (US) | 2015-07-22 | — | — | EP | disclosed |
| CN-102146084-B | 3-cyan-6-aminoquinoline derivatives, preparation method thereof and application thereof in medicines | JIANGSU HENGRUI MEDICINE CO | 2014-05-07 | — | — | CN | disclosed |
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | disclosed |
| CN-1419559-A | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2003-05-21 | — | — | CN | disclosed |
| CN-1320121-A | Substituted 3-cyanoquinolines as protein tyrosine kinase inhibitors | AMERICAN CYANAMID CO (US) | 2001-10-31 | — | — | CN | disclosed |
| CN-1320118-A | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors | AMERICAN CYANAMID CO (US) | 2001-10-31 | — | — | CN | disclosed |
| US-6297258-B1 | USEFUL AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE. | AMERICAN CYANAMID COMPANY | 2001-10-02 | — | — | US | disclosed |
| US-6288082-B1 | COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | disclosed |
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-1117649-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018740-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |