Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 16/20 | 0.81 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.70 |
| ▸ | GABRP | O00591 | 1/20 | 0.68 |
| ▸ | GABRD | O14764 | 1/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.68 |
| ▸ | PGR | P06401 | 1/20 | 0.68 |
| ▸ | KLK3 | P07288 | 1/20 | 0.68 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.68 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.68 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.68 |
| ▸ | CNR1 | P21554 | 1/20 | 0.68 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.68 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.68 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.68 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.68 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.68 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.68 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.68 |
| ▸ | GABRE | P78334 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10020938 | 0.92 | AR (0.81) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL565106 | 0.91 | ABCG2 (0.83) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL30946717 | 0.91 | ABCG2 (0.83) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL189993 | 0.91 | ABCG2 (0.85) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL24831438 | 0.91 | AR (0.82) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL565886 | 0.90 | AR (1.00) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL10052134 | 0.87 | AR (0.62) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL14932525 | 0.86 | AR (0.62) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL13160660 | 0.86 | AR (0.61) | ARABCG2GABRPGABRDNR1I2 | |
| SCHEMBL13160655 | 0.86 | AR (0.61) | ARABCG2GABRPGABRDNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210069154-A1 | Treatment of Breast Cancer | MEDIVATION PROSTATE THERAPEUTICS LLC | 2021-03-11 | — | — | US | disclosed |
| US-10626091-B2 | Process for the preparation of enzalutamide | LAURUS LABS LIMITED (IN) | 2020-04-21 | — | — | US | disclosed |
| US-20190262315-A1 | Treatment of Breast Cancer | MEDIVATION PROSTATE THERAPEUTICS, INC. | 2019-08-29 | — | — | US | disclosed |
| US-20190127332-A1 | PROCESS FOR THE PREPARATION OF ENZALUTAMIDE | LAURUS LABS LIMITED (IN) | 2019-05-02 | — | — | US | disclosed |
| US-20170313662-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE | LAURUS LABS LIMITED (IN) | 2017-11-02 | — | — | US | disclosed |
| US-20170313662-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE | LAURUS LABS LIMITED (IN) | 2017-11-02 | — | — | US | disclosed |
| US-20170087132-A1 | Treatment of Breast Cancer | MEDIVATION PROSTATE THERAPEUTICS LLC | 2017-03-30 | — | — | US | disclosed |
| US-9517229-B2 | Treatment of breast cancer | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2016-12-13 | — | — | US | disclosed |
| WO-2016051423-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE | LAURUS LABS PRIVATE LIMITED (IN) | 2016-04-07 | — | — | WO | disclosed |
| US-9023879-B2 | Specific diarylhydantoin and diarylthiohydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20130331421-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2013-12-12 | — | — | US | disclosed |
| US-8524755-B2 | Specific diarylhydantoin and diarylthiohydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524755-B2 | Specific diarylhydantoin and diarylthiohydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524755-B2 | Specific diarylhydantoin and diarylthiohydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120035231-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS LLC | 2012-02-09 | — | — | US | disclosed |
| US-20120035231-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS LLC | 2012-02-09 | — | — | US | disclosed |
| US-20120035231-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS LLC | 2012-02-09 | — | — | US | disclosed |
| EP-2400847-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | Medivation Prostate Therapeutics, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099238-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010099238-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313662-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE | KLK4, KLK5, KLK1 | AR 8/4885ABCG2 3861/4885GABRP 3414/4885 |
| US-20190127332-A1 | PROCESS FOR THE PREPARATION OF ENZALUTAMIDE | KLK4, KLK5, KLK1 | AR 8/4885ABCG2 3897/4885GABRP 2719/4885 |
| US-20130331421-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | BPHL, PARK7, APP | AR 266/4885ABCG2 1388/4885GABRP 4093/4885 |
| US-10626091-B2 | Process for the preparation of enzalutamide | KLK4, KLK5, KLK1 | AR 8/4885ABCG2 3897/4885GABRP 2719/4885 |
| US-20190262315-A1 | Treatment of Breast Cancer | BRCA1, TP53, TUBB6 | AR 2403/4885ABCG2 3583/4885GABRP 3568/4885 |
| US-20120035231-A1 | SPECIFIC DIARYLHYDANTOIN AND DIARYLTHIOHYDANTOIN COMPOUNDS | BPHL, PARK7, APP | AR 266/4885ABCG2 1388/4885GABRP 4093/4885 |
| US-20170087132-A1 | Treatment of Breast Cancer | BRCA1, MKI67, BAX | AR 2292/4885ABCG2 3067/4885GABRP 2593/4885 |
| US-20210069154-A1 | Treatment of Breast Cancer | BRCA1, TP53, TUBB6 | AR 2403/4885ABCG2 3583/4885GABRP 3568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.