Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11786492 | 0.86 | GAA (0.50) | ALDH1A1GAAKDM4EMEN1MAPT | |
| SCHEMBL12405380 | 0.84 | ALDH1A1 (0.51) | ALDH1A1GAAKDM4EMEN1MAPT | |
| SCHEMBL221405 | 0.84 | ALDH1A1 (0.51) | ALDH1A1GAAKDM4EMEN1MAPT | |
| SCHEMBL9150131 | 0.84 | ALDH1A1 (0.50) | ALDH1A1GAAKDM4EMEN1MAPT | |
| SCHEMBL221406 | 0.82 | CNR2 (0.53) | ALDH1A1GAAKDM4EMEN1MAPT | |
| SCHEMBL9519087 | 0.81 | GAA (0.46) | ALDH1A1GAAMEN1MAPTTHRB | |
| SCHEMBL35535 | 0.81 | ALDH1A1 (0.73) | ALDH1A1GAAKDM4EMEN1MAPT | |
| SCHEMBL29362042 | 0.81 | ALDH1A1 (0.73) | ALDH1A1GAAKDM4EMEN1MAPT | |
| SCHEMBL6142004 | 0.81 | ALDH1A1 (0.73) | ALDH1A1GAAKDM4EMEN1MAPT | |
| SCHEMBL27448454 | 0.80 | ATM (0.48) | ALDH1A1GAAKDM4EMAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10881656-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2021-01-05 | — | — | US | disclosed |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881656-B2 | HIF inhibitors and use thereof | HIF1AN, HIF1A, EGLN3 | ALDH1A1 595/4885GAA 1002/4885KDM4E 803/4885 |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | ALDH1A1 595/4885GAA 1002/4885KDM4E 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.