Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.44 |
| ▸ | PDE1A | P54750 | 7/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 7/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31715868 | 0.74 | PDE10A (0.45) | PDE10APDE1APDE1BPDE1C | |
| SCHEMBL18944430 | 0.73 | MAPT (0.51) | NPC1RAB9ASMN1; SMN2MAPTGFER | |
| SCHEMBL29376709 | 0.73 | PDE1A (0.43) | SMN1; SMN2PDE10APDE1APDE1BPDE1C | |
| SCHEMBL11175667 | 0.73 | MAPT (0.61) | NPC1RAB9ASMN1; SMN2MAPTGFER | |
| SCHEMBL10557404 | 0.72 | ALDH1A1 (0.74) | RAB9ASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL28736466 | 0.72 | PDE1A (0.47) | NPC1RAB9APDE10APDE1APDE1B | |
| SCHEMBL31716208 | 0.71 | HDAC8 (0.42) | SMN1; SMN2GFERPDE10APDE1APDE1B | |
| SCHEMBL28968809 | 0.70 | KMT2A (0.58) | SMN1; SMN2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL29120707 | 0.70 | MCHR1 (0.62) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL31212184 | 0.70 | LTA4H (0.49) | NPC1RAB9ASMN1; SMN2PDE10APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781661-B1 | VASOPRESSIN V1A ANTAGONISTS | VANTIA LTD (GB) | 2017-06-07 | — | — | EP | disclosed |