Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL28726469 | 1.00 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1KDM4ELMNAKCNH2 | |
| SCHEMBL467103 | 0.97 | SIGMAR1 (0.65) | SIGMAR1ALDH1A1KDM4ELMNAKCNH2 | |
| SCHEMBL5185066 | 0.87 | SIGMAR1 (0.72) | SIGMAR1KCNH2 | |
| Oxalic Acid SCHEMBL19691744 | 0.82 | SIGMAR1 (0.79) | SIGMAR1KDM4EKCNH2POLB | |
| Oxalic Acid SCHEMBL1897462 | 0.82 | SIGMAR1 (0.79) | SIGMAR1KDM4EKCNH2POLB | |
| SCHEMBL467214 | 0.82 | SIGMAR1 (0.67) | SIGMAR1KDM4EKCNH2 | |
| Oxalic Acid SCHEMBL19692414 | 0.82 | SIGMAR1 (0.78) | SIGMAR1KDM4EKCNH2POLB | |
| Oxalic Acid SCHEMBL1897458 | 0.82 | SIGMAR1 (0.78) | SIGMAR1KDM4EKCNH2POLB | |
| Hydrochloric Acid SCHEMBL1896086 | 0.81 | SIGMAR1 (0.66) | SIGMAR1KDM4EKCNH2 | |
| Oxalic Acid SCHEMBL1896696 | 0.80 | SIGMAR1 (0.94) | SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3463339-B1 | USE OF SIGMA RECEPTOR LIGANDS IN CANCER | ESTEVE PHARMACEUTICALS SA (ES) | 2023-12-06 | — | — | EP | disclosed |
| CN-109310672-B | Use of sigma receptor ligands in cancer | 埃斯特韦制药有限公司 | 2022-05-03 | — | — | CN | disclosed |
| US-20190142840-A1 | USE OF SIGMA RECEPTOR LIGANDS IN CANCER | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-05-16 | — | — | US | disclosed |
| WO-2019068771-A1 | USE OF SIGMA RECEPTOR LIGANDS IN AGE-RELATED COGNITIVE IMPAIRMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-04-11 | — | — | WO | disclosed |
| EP-3463339-A1 | USE OF SIGMA RECEPTOR LIGANDS IN CANCER | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-04-10 | — | — | EP | disclosed |
| EP-3328365-A1 | USE OF SIGMA RECEPTOR LIGANDS IN DYSLIPIDEMIA | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2018-06-06 | — | — | EP | disclosed |
| WO-2017211763-A1 | USE OF SIGMA RECEPTOR LIGANDS IN CANCER | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-12-14 | — | — | WO | disclosed |
| WO-2017211765-A1 | SIGMA LIGANDS FOR USE IN THE TREATMENT OF DIABETES AND METABOLIC SYNDROME | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-12-14 | — | — | WO | disclosed |
| US-20170273948-A1 | USE OF SIGMA RECEPTOR LIGANDS IN OSTEOARTHRITIS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2017-09-28 | — | — | US | disclosed |
| WO-2017021002-A1 | USE OF SIGMA RECEPTOR LIGANDS IN DYSLIPIDEMIA | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-02-09 | — | — | WO | disclosed |
| US-8293740-B2 | Sigma receptor inhibitors | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2012-10-23 | — | — | US | disclosed |
| EP-1781618-B1 | SIGMA RECEPTOR INHIBITORS | ESTEVE LABOR DR (ES) | 2012-10-03 | — | — | EP | disclosed |
| EP-2325174-A1 | Sigma receptor inhibitors | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-05-25 | — | — | EP | disclosed |
| US-20100190780-A1 | SIGMA RECEPTOR INHIBITORS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2010-07-29 | — | — | US | disclosed |
| US-20100190781-A1 | SIGMA RECEPTOR INHIBITORS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2010-07-29 | — | — | US | disclosed |
| US-20100190790-A1 | SIGMA RECEPTOR INHIBITORS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2010-07-29 | — | — | US | disclosed |
| US-7696199-B2 | Sigma receptor inhibitors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-04-13 | — | — | US | disclosed |
| US-20080125416-A1 | Sigma Receptor Inhibitors | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2008-05-29 | — | — | US | disclosed |
| EP-1781618-A1 | SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006021462-A1 | SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190142840-A1 | USE OF SIGMA RECEPTOR LIGANDS IN CANCER | SIGMAR1, TMEM97, OPRL1 | SIGMAR1 1/4885ALDH1A1 547/4885KDM4E 4113/4885 |
| US-20100190790-A1 | SIGMA RECEPTOR INHIBITORS | SIGMAR1, TMEM97, OPRL1 | SIGMAR1 1/4885ALDH1A1 777/4885KDM4E 4559/4885 |
| US-20080125416-A1 | Sigma Receptor Inhibitors | SIGMAR1, TMEM97, OPRL1 | SIGMAR1 1/4885ALDH1A1 777/4885KDM4E 4559/4885 |
| US-20170273948-A1 | USE OF SIGMA RECEPTOR LIGANDS IN OSTEOARTHRITIS | SIGMAR1, OPRL1, OPRK1 | SIGMAR1 1/4885ALDH1A1 561/4885KDM4E 4332/4885 |
| US-20100190781-A1 | SIGMA RECEPTOR INHIBITORS | SIGMAR1, TMEM97, OPRL1 | SIGMAR1 1/4885ALDH1A1 777/4885KDM4E 4559/4885 |
| US-20100190780-A1 | SIGMA RECEPTOR INHIBITORS | SIGMAR1, TMEM97, OPRL1 | SIGMAR1 1/4885ALDH1A1 777/4885KDM4E 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.