Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 17/20 | 0.51 |
| ▸ | GLS | O94925 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18890300 | 0.81 | GLS (0.52) | GLS | |
| SCHEMBL18890299 | 0.78 | HRH4 (0.47) | HRH4GLSHRH3 | |
| SCHEMBL29544097 | 0.78 | HRH4 (0.47) | HRH4GLSHRH3 | |
| SCHEMBL18890294 | 0.77 | JAK3 (0.52) | GLS | |
| SCHEMBL29544074 | 0.77 | JAK3 (0.52) | GLS | |
| SCHEMBL18945892 | 0.77 | JAK3 (0.52) | GLS | |
| SCHEMBL19513509 | 0.77 | HRH4 (0.62) | HRH4HRH3 | |
| SCHEMBL18890288 | 0.76 | GLS (0.57) | GLS | |
| SCHEMBL21336454 | 0.76 | GLS (0.57) | GLS | |
| SCHEMBL29543830 | 0.76 | GLS (0.57) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383871-B1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-09-11 | — | — | EP | disclosed |
| WO-2017093300-A1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-06-08 | — | — | WO | disclosed |