Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 7/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12076546 | 0.97 | HIF1A (0.52) | HIF1AEPAS1BCHEACHERORC | |
| SCHEMBL1863758 | 0.82 | RORC (0.52) | HIF1AEPAS1RORCCCR3MEN1 | |
| SCHEMBL1871271 | 0.79 | HIF1A (0.55) | HIF1AEPAS1RORCCCR3DNMT1 | |
| SCHEMBL1869907 | 0.78 | CCR3 (0.58) | HIF1AEPAS1RORCCCR3MEN1 | |
| SCHEMBL1873273 | 0.77 | CCR3 (0.58) | HIF1AEPAS1RORCCCR3MEN1 | |
| SCHEMBL1862776 | 0.77 | HIF1A (0.71) | HIF1AEPAS1RORCCCR3DNMT1 | |
| SCHEMBL1869122 | 0.77 | HIF1A (0.57) | HIF1AEPAS1RORCCCR3MEN1 | |
| SCHEMBL1870500 | 0.76 | HIF1A (0.59) | HIF1AEPAS1RORCCCR3DNMT1 | |
| SCHEMBL12458982 | 0.76 | HIF1A (0.56) | HIF1AEPAS1RORCCCR3DNMT1 | |
| SCHEMBL12274806 | 0.75 | CCR3 (0.54) | HIF1AEPAS1RORCCCR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051282-A1 | (1,1, 1,3, 3, 3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS | N.V. ORGANON (NL) | 2011-05-05 | — | — | WO | disclosed |