Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 4/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.52 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.52 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.52 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870500 | 0.84 | HIF1A (0.59) | HIF1AEPAS1RORCCCR3KMT2A | |
| SCHEMBL1869907 | 0.84 | CCR3 (0.58) | HIF1AEPAS1RORCCCR3KMT2A | |
| SCHEMBL1862776 | 0.83 | HIF1A (0.71) | HIF1AEPAS1RORCCCR3KMT2A | |
| SCHEMBL1869122 | 0.83 | HIF1A (0.57) | HIF1AEPAS1RORCCCR3TP53 | |
| SCHEMBL12274057 | 0.82 | SIGMAR1 (0.57) | HIF1AEPAS1RORCCCR3KMT2A | |
| SCHEMBL1873273 | 0.82 | CCR3 (0.58) | HIF1AEPAS1RORCCCR3KMT2A | |
| SCHEMBL1871271 | 0.82 | HIF1A (0.55) | HIF1AEPAS1RORCCCR3TP53 | |
| SCHEMBL12076505 | 0.81 | HIF1A (0.51) | HIF1AEPAS1RORCCCR3KMT2A | |
| SCHEMBL1872044 | 0.81 | HIF1A (0.55) | HIF1AEPAS1RORCCCR3KMT2A | |
| SCHEMBL1865420 | 0.80 | HIF1A (0.58) | HIF1AEPAS1RORCCCR3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108939-B2 | (1, 1, 1,3,3,3-hexafluoro-2 hydroxypropan-2-yl) phenyl derivative, pharmaceutical compositions thereof and their use for the treatment of atherosclerosis | MERCK SHARP & DOHME B.V. (NL) | 2015-08-18 | — | — | US | disclosed |
| US-9108939-B2 | (1, 1, 1,3,3,3-hexafluoro-2 hydroxypropan-2-yl) phenyl derivative, pharmaceutical compositions thereof and their use for the treatment of atherosclerosis | MERCK SHARP & DOHME B.V. (NL) | 2015-08-18 | — | — | US | disclosed |
| EP-2493855-B1 | (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl derivatives, pharmaceutical compositions thereof and their use for the treatment of atherosclerosis | MERCK SHARP & DOHME (NL) | 2014-02-26 | — | — | EP | disclosed |
| US-20120238574-A1 | (1, 1, 1,3,3,3 -HEXAFLUORO-2 HYDROXYPROPAN- 2 -YL) PHENYL DERIVATIVE, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS | N.V. ORGANON (NL) | 2012-09-20 | — | — | US | disclosed |
| US-20120238574-A1 | (1, 1, 1,3,3,3 -HEXAFLUORO-2 HYDROXYPROPAN- 2 -YL) PHENYL DERIVATIVE, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS | N.V. ORGANON (NL) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238574-A1 | (1, 1, 1,3,3,3 -HEXAFLUORO-2 HYDROXYPROPAN- 2 -YL) PHENYL DERIVATIVE, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS | TGFB1, FPR1, TGFB2 | HIF1A 104/4885EPAS1 204/4885FAAH 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.