Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16553601 | 0.89 | HTT (0.62) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL3656920 | 0.86 | HTT (0.68) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL30869144 | 0.83 | HTT (0.58) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL19384905 | 0.82 | HTT (0.64) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL13055383 | 0.81 | LMNA (0.80) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL22214968 | 0.81 | HTT (0.63) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL12409525 | 0.81 | HTT (0.62) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL12712296 | 0.81 | TGM2 (0.63) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL11048765 | 0.79 | LMNA (0.63) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL7514786 | 0.79 | HTT (0.73) | HTTLMNASMN1; SMN2TGM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036236-B1 | NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II | LEO PHARMA AS (DK) | 2017-06-07 | — | — | EP | disclosed |