Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20052787 | 1.00 | CYP2D6 (0.41) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL19890344 | 1.00 | CYP2D6 (0.41) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL21362944 | 1.00 | CYP2D6 (0.41) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL18638711 | 0.98 | FAAH (0.40) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL19225133 | 0.98 | FAAH (0.40) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL21362869 | 0.98 | CYP2D6 (0.41) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL25771267 | 0.97 | CYP2D6 (0.41) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL22308557 | 0.93 | NR1I2 (0.40) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL26078439 | 0.93 | NR1I2 (0.40) | CYP2D6FAAHNR1I2CYP3A4NAAA | |
| SCHEMBL23709521 | 0.93 | CYP2D6 (0.42) | CYP2D6FAAHCYP3A4NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9675593-B2 | Anti-fibrotic pyridinones | INTERMUNE, INC. (US) | 2017-06-13 | — | — | US | disclosed |