Known targets — ChEMBL curated mechanism
ATP1A1ATP1A2ATP1A3ATP1A4ATP1B1ATP1B2ATP1B3FXYD2
The experimentally established mechanism targets of Lanatoside C. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP1A1 known ✓ | P05023 | 12/20 | 0.71 |
| ▸ | ATP1B1 known ✓ | P05026 | 12/20 | 0.71 |
| ▸ | ATP1A2 known ✓ | P50993 | 12/20 | 0.71 |
| ▸ | ATP1B2 known ✓ | P14415 | 11/20 | 0.71 |
| ▸ | ATP1B3 known ✓ | P54709 | 11/20 | 0.71 |
| ▸ | ATP1A3 known ✓ | P13637 | 1/20 | 0.71 |
| ▸ | FXYD2 known ✓ | P54710 | 1/20 | 0.71 |
| ▸ | ATP1A4 known ✓ | Q13733 | 1/20 | 0.71 |
| ▸ | PAX8 | Q06710 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.89 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.71 |
| ▸ | STAT3 | P40763 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | RORC | P51449 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lanatoside C SCHEMBL20582682 | 1.00 | PAX8 (1.00) | PAX8LMNATP53SMN1; SMN2THRB | |
| Lanatoside C SCHEMBL18223891 | 1.00 | PAX8 (1.00) | PAX8LMNATP53SMN1; SMN2THRB | |
| Lanatoside C SCHEMBL18277653 | 1.00 | PAX8 (1.00) | PAX8LMNATP53SMN1; SMN2THRB | |
| Lanatoside C SCHEMBL18364709 | 1.00 | PAX8 (1.00) | PAX8LMNATP53SMN1; SMN2THRB | |
| Lanatoside C SCHEMBL44110 | 1.00 | PAX8 (1.00) | PAX8LMNATP53SMN1; SMN2THRB | |
| Lanatoside C SCHEMBL23054706 | 1.00 | PAX8 (1.00) | PAX8LMNATP53SMN1; SMN2THRB | |
| Lanatoside C SCHEMBL15959375 | 1.00 | PAX8 (1.00) | PAX8LMNATP53SMN1; SMN2THRB | |
| SCHEMBL18949552 | 0.97 | PAX8 (0.94) | PAX8LMNATP53SMN1; SMN2THRB | |
| SCHEMBL24837992 | 0.97 | PAX8 (0.94) | PAX8LMNATP53SMN1; SMN2THRB | |
| SCHEMBL20251039 | 0.97 | PAX8 (0.94) | PAX8LMNATP53SMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9675623-B2 | Non-surgical method of treatment for cataract | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-06-13 | — | — | US | disclosed |
| US-9675623-B2 | Non-surgical method of treatment for cataract | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-06-13 | — | — | US | disclosed |