Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.34 |
| ▸ | GABRP | O00591 | 4/20 | 0.34 |
| ▸ | GABRD | O14764 | 4/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.34 |
| ▸ | GABRE | P78334 | 4/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16019486 | 0.83 | CA5A (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL16019479 | 0.72 | HTR2A (0.49) | CA5A | |
| SCHEMBL16019430 | 0.68 | CA5A (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL16019487 | 0.67 | CA5A (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL16019514 | 0.66 | CA5A (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL16019490 | 0.65 | CA5A (0.40) | CA5AMAPT | |
| SCHEMBL7517822 | 0.61 | KIF11 (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL16009917 | 0.59 | PDK2 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6648375 | 0.59 | TSHR (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18949691 | 0.58 | KIF11 (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9675697-B2 | BET bromodomain inhibitors and therapeutic methods using the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-06-13 | — | — | US | disclosed |