Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 9/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27365771 | 0.87 | PNMT (0.40) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL23603132 | 0.80 | CES2 (0.46) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL657090 | 0.80 | IDO1 (0.46) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL4145700 | 0.80 | CES2 (0.46) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL15828511 | 0.79 | KDM4E (0.45) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL15440915 | 0.79 | KDM4E (0.45) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL3952470 | 0.79 | KDM4E (0.45) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL15441184 | 0.79 | KDM4E (0.45) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL531415 | 0.79 | KDM4E (0.45) | PNMTIDO1CES2TDO2TACR1 | |
| SCHEMBL15441219 | 0.79 | KDM4E (0.45) | PNMTIDO1CES2TDO2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2837624-B1 | 4-SUBSTITUENT-2-HYDROXYLMORPHOLINE-3-ONE AND PREPARATION METHOD THEREOF | ZHEJIANG HISUN PHARM CO LTD (CN) | 2018-06-27 | — | — | EP | disclosed |
| US-9676736-B2 | 4-substituent-2-hydroxylmorpholine-3-one and preparation method thereof | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2017-06-13 | — | — | US | disclosed |