Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NAAA | Q02083 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921872 | 0.84 | SMN1; SMN2 (0.55) | GAAMAPK1HTTSMN1; SMN2NAAA | |
| SCHEMBL13387564 | 0.82 | GAA (0.59) | GAAMAPK1HTTSMN1; SMN2NAAA | |
| SCHEMBL4719490 | 0.82 | GAA (0.59) | GAAMAPK1HTTSMN1; SMN2NAAA | |
| SCHEMBL4473083 | 0.81 | GAA (0.46) | GAAMAPK1HTTSMN1; SMN2NAAA | |
| SCHEMBL26677284 | 0.79 | EPHX1 (0.59) | GAAMAPK1HTTSMN1; SMN2NAAA | |
| SCHEMBL1827279 | 0.79 | EPHX1 (0.64) | GAAMAPK1HTTSMN1; SMN2EPHX1 | |
| SCHEMBL16377759 | 0.79 | SMN1; SMN2 (0.50) | GAAMAPK1HTTSMN1; SMN2NAAA | |
| SCHEMBL2801497 | 0.78 | EPHX1 (0.67) | GAAMAPK1HTTSMN1; SMN2EPHX1 | |
| SCHEMBL22801974 | 0.78 | GAA (0.51) | GAAMAPK1HTTSMN1; SMN2NAAA | |
| SCHEMBL3332407 | 0.78 | NAAA (0.52) | GAAMAPK1HTTSMN1; SMN2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676783-B2 | Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds | ARRAY BIOPHARMA, INC. (US) | 2017-06-13 | — | — | US | disclosed |