Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16377759 | 0.94 | SMN1; SMN2 (0.50) | SMN1; SMN2GAAMAPK1HTTEPHX1 | |
| SCHEMBL4719490 | 0.87 | GAA (0.59) | SMN1; SMN2GAAMAPK1HTTEPHX1 | |
| SCHEMBL13387564 | 0.87 | GAA (0.59) | SMN1; SMN2GAAMAPK1HTTEPHX1 | |
| SCHEMBL8534730 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2GAAMAPK1HTTEPHX1 | |
| SCHEMBL18950347 | 0.84 | GAA (0.54) | SMN1; SMN2GAAMAPK1HTTEPHX1 | |
| SCHEMBL12039329 | 0.83 | DRD2 (0.50) | HSD11B1NFKB1NFKB2KMT2ARELA | |
| SCHEMBL1827279 | 0.83 | EPHX1 (0.64) | SMN1; SMN2GAAMAPK1HTTEPHX1 | |
| SCHEMBL26677284 | 0.83 | EPHX1 (0.59) | SMN1; SMN2GAAMAPK1HTTEPHX1 | |
| SCHEMBL13102981 | 0.83 | EPHX1 (0.44) | SMN1; SMN2GAAMAPK1HTTEPHX1 | |
| SCHEMBL30364252 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2GAAMAPK1HTTEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011038164-A1 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2011-03-31 | — | — | WO | disclosed |