SCHEMBL18950765

SCHEMBL18950765

COc1c(-c2cc(C(C)(C)C)cc(C(C)(C)C)c2OP(C)Cl)cc(C(C)(C)C)cc1C(C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.34
TSHR P16473 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
RARG P13631 1/20 0.34
RXRA P19793 1/20 0.34
PPARG P37231 1/20 0.34
PTGS2 P35354 1/20 0.32
HSP90AA1 P07900 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17285589 0.89 HSP90AA1 (0.35) ALDH1A1TSHRTDP1RARGRXRA
SCHEMBL14817161 0.85 RARG (0.40) ALDH1A1TSHRTDP1RARGRXRA
SCHEMBL7147241 0.79 HSP90AA1 (0.36) RARGRXRAPPARGHSP90AA1
SCHEMBL18950767 0.76 HSP90AA1 (0.35) ALDH1A1TSHRTDP1RARGRXRA
SCHEMBL18191801 0.76 MAPT (0.33) ALDH1A1RARGRXRAPPARG
SCHEMBL17274610 0.76 HSP90AA1 (0.50) ALDH1A1TSHRRARGRXRAPPARG
SCHEMBL2947022 0.75 PTGS2 (0.47) ALDH1A1TSHRTDP1RARGRXRA
SCHEMBL4018841 0.75 HSP90AA1 (0.38) ALDH1A1TSHRRARGRXRAPPARG
SCHEMBL17285536 0.73 CA1 (0.49) ALDH1A1TSHRTDP1PTGS2
SCHEMBL18926391 0.73 ALDH1A1 (0.40) ALDH1A1TSHRTDP1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3178828-A1 HETEROCYCLIC SELENA PHOSPHITES AND METHOD FOR THE PRODUCTION THEREOF Evonik Degussa GmbH (DE) 2017-06-14 EP disclosed