Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895148 | 1.00 | PDK1 (0.53) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL1126893 | 0.76 | KMT2A (0.53) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL9987490 | 0.74 | PDK1 (0.73) | PDK1PDK2PDK3PDK4KDM4E | |
| Hydrochloric Acid SCHEMBL1786105 | 0.72 | PDK1 (0.55) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL5176786 | 0.71 | PDK1 (0.53) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL3783627 | 0.70 | GPR35 (0.57) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL3527090 | 0.70 | TSHR (0.61) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL7625221 | 0.70 | PDK1 (0.51) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL11651734 | 0.69 | PDK1 (0.49) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL11655479 | 0.69 | PDK1 (0.49) | PDK1PDK2PDK3PDK4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |