Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31360017 | 0.84 | ALDH1A1 (0.43) | ALDH1A1MAPK1SLC6A3HPGD | |
| SCHEMBL25155914 | 0.84 | ALDH1A1 (0.43) | ALDH1A1MAPK1SLC6A3HPGD | |
| SCHEMBL18952107 | 0.81 | PTGS2 (0.43) | SLC6A3NPC1MEN1KMT2AFGFR1 | |
| SCHEMBL20491056 | 0.81 | PTGS2 (0.43) | SLC6A3AKT1AKT2PDK2 | |
| SCHEMBL25155269 | 0.78 | NOTUM (0.40) | ALDH1A1MAPK1NPC1AURKACDK1 | |
| SCHEMBL31360144 | 0.78 | NOTUM (0.40) | ALDH1A1MAPK1NPC1AURKACDK1 | |
| SCHEMBL24582841 | 0.77 | MAPT (0.40) | SLC6A3NPC1MEN1KMT2AMAPT | |
| SCHEMBL646392 | 0.73 | HTR2A (0.43) | — | |
| SCHEMBL29669136 | 0.73 | HTR2A (0.43) | — | |
| SCHEMBL19125933 | 0.72 | ALDH1A1 (0.63) | ALDH1A1MAPK1PTPRCSLC6A3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017097865-A9 | COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR | ISTITUTO EUROPEO DI ONCOLOGIA (IT) | 2017-08-31 | — | — | WO | disclosed |
| WO-2017097865-A1 | COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR | ISTITUTO EUROPEO DI ONCOLOGIA (IT) | 2017-06-15 | — | — | WO | disclosed |