Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 known ✓ | P30542 | 3/20 | 0.58 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.58 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.58 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.58 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.58 |
| ▸ | GAPDH | P04406 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | STAT6 | P42226 | 1/20 | 0.58 |
| ▸ | PI4KA | P42356 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.58 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.58 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.58 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL27686613 | 0.97 | P2RY2 (0.65) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL9419203 | 0.95 | ADORA1 (0.63) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL28057366 | 0.91 | ADORA1 (0.67) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL3043097 | 0.91 | P2RY2 (0.58) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine Diphosphate SCHEMBL30751027 | 0.90 | P2RY1 (0.72) | P2RY2ADORA1SMN1; SMN2P2RY1SRC | |
| Adenosine Diphosphate SCHEMBL22498771 | 0.90 | P2RY1 (0.72) | P2RY2ADORA1SMN1; SMN2P2RY1SRC | |
| Adenosine Diphosphate SCHEMBL424711 | 0.90 | P2RY1 (0.72) | P2RY2ADORA1SMN1; SMN2P2RY1SRC | |
| Adenosine SCHEMBL21067523 | 0.90 | P2RY2 (0.62) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL2327105 | 0.90 | ADORA3 (0.72) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL26612876 | 0.90 | ADORA3 (0.72) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386510-B1 | PHOSPHOROUS DERIVATIVES FOR THE PREVENTION OR TREATMENT OF MUSCULAR MYOPATHIES AND TRAUMATIC INJURIES TO MUSCLES | CENTRE NAT RECH SCIENT (FR) | 2024-01-31 | — | — | EP | disclosed |
| EP-3386510-A2 | CARBOLINE DERIVATIVES OR PHOSPHOROUS DERIVATIVES FOR THE PREVENTION OR TREATMENT OF MUSCULAR MYOPATHIES AND TRAUMATIC INJURIES TO MUSCLES | Centre National De La Recherche Scientifique (FR) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098173-A2 | COMPOUNDS, AND COMPOSITIONS COMPRISING SUCH COMPOUNDS FOR THE PREVENTION OR TREATMENT OF MUSCULAR MYOPATHIES AND TRAUMATIC INJURIES TO MUSCLES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2017-06-15 | — | — | WO | disclosed |