Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 known ✓ | P30542 | 3/20 | 0.55 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.55 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.55 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.55 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.55 |
| ▸ | GAPDH | P04406 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | STAT6 | P42226 | 1/20 | 0.55 |
| ▸ | PI4KA | P42356 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.55 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.55 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL27686613 | 0.94 | P2RY2 (0.65) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL9419203 | 0.92 | ADORA1 (0.63) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL18953147 | 0.91 | P2RY2 (0.62) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL28057366 | 0.89 | ADORA1 (0.67) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine Diphosphate SCHEMBL30751027 | 0.88 | P2RY1 (0.72) | P2RY2ADORA1SMN1; SMN2P2RY1SRC | |
| Adenosine Diphosphate SCHEMBL22498771 | 0.88 | P2RY1 (0.72) | P2RY2ADORA1SMN1; SMN2P2RY1SRC | |
| Adenosine Diphosphate SCHEMBL424711 | 0.88 | P2RY1 (0.72) | P2RY2ADORA1SMN1; SMN2P2RY1SRC | |
| Adenosine SCHEMBL21067523 | 0.88 | P2RY2 (0.62) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL2327105 | 0.87 | ADORA3 (0.72) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL26612876 | 0.87 | ADORA3 (0.72) | P2RY2ADORA1SMN1; SMN2DPP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741295-B2 | Sir2 products and activities | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2010-06-22 | — | — | US | disclosed |
| EP-1453848-A4 | SIR2 PRODUCTS AND ACTIVITIES | EINSTEIN COLL MED (US) | 2009-09-09 | — | — | EP | disclosed |
| US-20090068695-A1 | Sir2 products and activities | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-12 | — | — | US | disclosed |
| US-7432246-B2 | Sir2 products and activities | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2008-10-07 | — | — | US | disclosed |
| US-20060058520-A1 | Detecting activity of a Silent information regulator 2 by combining the composition with adenosine 5'-diphosphate and an acetylated Sir2 peptide substrate to deacetylate the peptide, and identifying 2'/3'-O-acetyl-ADP-ribose in the mixture to determine the presence of Sir2 activity | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2006-03-16 | — | — | US | disclosed |
| US-6987091-B2 | Sir2 products and activities | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-01-17 | — | — | US | disclosed |
| EP-1453848-A2 | SIR2 PRODUCTS AND ACTIVITIES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2004-09-08 | — | — | EP | disclosed |
| US-20030149261-A1 | Sir2 products and activities | NATIONAL INSTITUTES OF HEALTH | 2003-08-07 | — | — | US | disclosed |
| WO-2003045907-A2 | SIR2 PRODUCTS AND ACTIVITIES | ALBERT EINSTEIN COLLEGE OF MEDECINE OF YESHIVA UNIVERSITY (US) | 2003-06-05 | — | — | WO | disclosed |