Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | OXTR | P30559 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15583907 | 0.92 | HPGD (0.70) | HPGDMAPTOXTRPOLBKMT2A | |
| SCHEMBL16557554 | 0.91 | MAPT (0.72) | HPGDMAPTPOLB | |
| SCHEMBL15583958 | 0.89 | HPGD (0.67) | HPGDMAPTPOLBKMT2A | |
| SCHEMBL15584053 | 0.88 | HPGD (0.66) | HPGDMAPTPOLBKMT2A | |
| SCHEMBL18962718 | 0.85 | OXTR (0.75) | HPGDMAPTOXTRPOLB | |
| SCHEMBL15583879 | 0.85 | HPGD (0.62) | HPGDMAPTPOLBKMT2A | |
| SCHEMBL16557547 | 0.84 | HPGD (0.74) | HPGDMAPTPKMPOLBKMT2A | |
| SCHEMBL15583931 | 0.83 | MAPT (0.75) | HPGDMAPTPOLB | |
| SCHEMBL16557611 | 0.83 | OXTR (0.66) | HPGDMAPTOXTRKMT2A | |
| SCHEMBL16557429 | 0.83 | MEN1 (0.63) | HPGDMAPTOXTRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | HPGD 2/4885MAPT 4311/4885OXTR 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.