Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28506544 | 0.90 | PPARG (0.43) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL28515429 | 0.88 | PPARG (0.43) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL18960386 | 0.81 | MAP4K4 (0.44) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL28245881 | 0.81 | MEN1 (0.44) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL11169364 | 0.81 | MAPT (0.49) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL26137908 | 0.81 | KMT2A (0.44) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL18957388 | 0.81 | BCAT2 (0.50) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL19421238 | 0.78 | MAPT (0.41) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL11261915 | 0.77 | SMN1; SMN2 (0.48) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL5526629 | 0.77 | MEN1 (0.41) | MEN1KMT2AL3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017100668-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-15 | — | — | WO | disclosed |