Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18960378 | 0.81 | MEN1 (0.46) | MAP4K4MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL18957388 | 0.78 | BCAT2 (0.50) | MAP4K4MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL28245881 | 0.78 | MEN1 (0.44) | MAP4K4MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL11169364 | 0.78 | MAPT (0.49) | MAP4K4MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL26137908 | 0.78 | KMT2A (0.44) | MAP4K4MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL19421238 | 0.75 | MAPT (0.41) | MAP4K4MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL18774086 | 0.74 | NNMT (0.48) | KMT2ACYP1A2HTTALDH1A1TDP1 | |
| SCHEMBL16511924 | 0.74 | MAP4K4 (0.54) | MAP4K4MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL5526629 | 0.74 | MEN1 (0.41) | MAP4K4MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL16805396 | 0.74 | L3MBTL1 (0.49) | MAPTMAPK1L3MBTL1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017100668-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-15 | — | — | WO | disclosed |