Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 4/20 | 1.00 |
| ▸ | IDO1 | P14902 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18963232 | 0.86 | RRM1 (0.81) | RRM1HTTKDM4ENPC1ALDH1A1 | |
| SCHEMBL18963309 | 0.84 | RRM1 (0.78) | RRM1IDO1HTTKDM4ENPC1 | |
| SCHEMBL18963253 | 0.84 | RRM1 (1.00) | RRM1IDO1HTTKDM4ENPC1 | |
| SCHEMBL18963244 | 0.83 | RRM1 (1.00) | RRM1IDO1HTTKDM4ENPC1 | |
| SCHEMBL21649940 | 0.77 | RRM1 (0.67) | RRM1HTTKDM4ENPC1ALDH1A1 | |
| SCHEMBL21649936 | 0.77 | RRM1 (0.66) | RRM1IDO1HTTKDM4ENPC1 | |
| SCHEMBL14905767 | 0.77 | ALDH1A1 (0.75) | RRM1HTTKDM4ENPC1ALDH1A1 | |
| SCHEMBL18963233 | 0.76 | RRM1 (0.71) | RRM1IDO1HTTKDM4ENPC1 | |
| SCHEMBL15347364 | 0.76 | RRM1 (0.64) | RRM1IDO1HTTKDM4EALDH1A1 | |
| SCHEMBL13479598 | 0.76 | RRM1 (0.64) | RRM1IDO1HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017100644-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-06-15 | — | — | WO | disclosed |